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Alzheimer : 100 years and beyond / Yves Christen
Titre : Alzheimer : 100 years and beyond Type de document : texte imprimé Auteurs : Yves Christen, Editeur scientifique ; M. Jucker, Auteur ; K. Beyreuther, Auteur ; C. Haass, Auteur ; R. Nitsch, Auteur Editeur : Berlin : Springer Année de publication : 2006 Collection : Research and perspectives in Alzheimer's disease, ISSN 0945-6066 Importance : XXXIII-543 p. Présentation : 143 fig. (partly col.) Format : 24 cm. ISBN/ISSN/EAN : 978-3-540-37651-4 Langues : Anglais Catégories : Maladies:Etude des maladies:Maladie d'Alzheimer
Neurosciences - Santé mentale:Santé mentale
Personne humaine:Corps humain - Etapes de la vie:VieillissementMots-clés : "Alzheimer_Maladie--Congrès" Résumé : .
Few medical or scientific addresses have so unmistakeably made history as the presentation delivered by Alois Alzheimer on November 4th, 1906 in Tübingen. The celebratory event, "Alzheimer 100 Years and Beyond" organized on the initiative of the Alzheimer community in Germany and worldwide, in collaboration with the Fondation Ipsen, at the very site of the original lecture, namely the Institute of Psychiatry at the University of Tübingen in Germany from November 2nd to 5th, 2006, was the highlight of the Alzheimer Year. Over the last century of Alzheimer research (1906-2006), remarkable progress has been achieved. Most of the authors of the major discoveries and the people involved in research in this field will present, during the meeting and in this volume, the pioneering research explaining the conditions under which they were conducted. The goal of this book is to honor the work accomplished, to summarize the most important knowledge and to provide material for the history of science.Permalink : http://www.2em.org/pmb/opac_css/index.php?lvl=notice_display&id=3528 Alzheimer : 100 years and beyond [texte imprimé] / Yves Christen, Editeur scientifique ; M. Jucker, Auteur ; K. Beyreuther, Auteur ; C. Haass, Auteur ; R. Nitsch, Auteur . - Berlin : Springer, 2006 . - XXXIII-543 p. : 143 fig. (partly col.) ; 24 cm.. - (Research and perspectives in Alzheimer's disease, ISSN 0945-6066) .
ISBN : 978-3-540-37651-4
Langues : Anglais
Catégories : Maladies:Etude des maladies:Maladie d'Alzheimer
Neurosciences - Santé mentale:Santé mentale
Personne humaine:Corps humain - Etapes de la vie:VieillissementMots-clés : "Alzheimer_Maladie--Congrès" Résumé : .
Few medical or scientific addresses have so unmistakeably made history as the presentation delivered by Alois Alzheimer on November 4th, 1906 in Tübingen. The celebratory event, "Alzheimer 100 Years and Beyond" organized on the initiative of the Alzheimer community in Germany and worldwide, in collaboration with the Fondation Ipsen, at the very site of the original lecture, namely the Institute of Psychiatry at the University of Tübingen in Germany from November 2nd to 5th, 2006, was the highlight of the Alzheimer Year. Over the last century of Alzheimer research (1906-2006), remarkable progress has been achieved. Most of the authors of the major discoveries and the people involved in research in this field will present, during the meeting and in this volume, the pioneering research explaining the conditions under which they were conducted. The goal of this book is to honor the work accomplished, to summarize the most important knowledge and to provide material for the history of science.Permalink : http://www.2em.org/pmb/opac_css/index.php?lvl=notice_display&id=3528 Exemplaires
Code-barres Cote Support Disponibilité 11522 08CHR Ouvrage Disponible Apolipoprotein E and Alzheimer's disease / Yves Christen
Titre : Apolipoprotein E and Alzheimer's disease Type de document : texte imprimé Auteurs : Yves Christen, Editeur scientifique ; K. H. Weisgraber, Editeur scientifique ; Allen D. Roses, Editeur scientifique Editeur : Berlin : Springer Année de publication : 1996 Collection : Research and perspectives in Alzheimer's disease, ISSN 0945-6066 Importance : xx, 188 p. Présentation : ill. (some col.) Format : 24 cm ISBN/ISSN/EAN : 978-3-540-60798-4 Note générale : Papers presented at an international meeting held in Paris on May 29, 1995 Langues : Anglais Catégories : Maladies:Etude des maladies:Maladie d'Alzheimer
Neurosciences - Santé mentale:CerveauMots-clés : "Maladie_Alzheimer--Congrès" "Maladie_Alzheimer--Étiologie--Congrès" "Apolipoproteine_E" Résumé : .
There is now considerable genetic evidence that the type 4 allele of the apolipoprotein E gene is a major susceptibility factor associated with late-onset Alzheimer's disease, the common form of the disease defined as starting after sixty years of age. The role of apolipoprotein E in normal brain metabolism and in the pathogenesis of Alzheimer's disease are new and exciting avenues of research. This book, written by the most outstanding scientists in this new field, is the first presentation of results concerning the implications of apolipoprotein E on the genetics, cell biology, neuropathology, biochemistry, and therapeutic management of Alzheimer's disease.Permalink : http://www.2em.org/pmb/opac_css/index.php?lvl=notice_display&id=1840 Apolipoprotein E and Alzheimer's disease [texte imprimé] / Yves Christen, Editeur scientifique ; K. H. Weisgraber, Editeur scientifique ; Allen D. Roses, Editeur scientifique . - Berlin : Springer, 1996 . - xx, 188 p. : ill. (some col.) ; 24 cm. - (Research and perspectives in Alzheimer's disease, ISSN 0945-6066) .
ISBN : 978-3-540-60798-4
Papers presented at an international meeting held in Paris on May 29, 1995
Langues : Anglais
Catégories : Maladies:Etude des maladies:Maladie d'Alzheimer
Neurosciences - Santé mentale:CerveauMots-clés : "Maladie_Alzheimer--Congrès" "Maladie_Alzheimer--Étiologie--Congrès" "Apolipoproteine_E" Résumé : .
There is now considerable genetic evidence that the type 4 allele of the apolipoprotein E gene is a major susceptibility factor associated with late-onset Alzheimer's disease, the common form of the disease defined as starting after sixty years of age. The role of apolipoprotein E in normal brain metabolism and in the pathogenesis of Alzheimer's disease are new and exciting avenues of research. This book, written by the most outstanding scientists in this new field, is the first presentation of results concerning the implications of apolipoprotein E on the genetics, cell biology, neuropathology, biochemistry, and therapeutic management of Alzheimer's disease.Permalink : http://www.2em.org/pmb/opac_css/index.php?lvl=notice_display&id=1840 Exemplaires
Code-barres Cote Support Disponibilité 11526 08CHR Ouvrage Disponible Connections, cognition and Alzheimer's disease / Hyman, B. T. ; Duyckaerts, C. ; Yves Christen
Titre : Connections, cognition and Alzheimer's disease Type de document : texte imprimé Auteurs : Hyman, B. T., Editeur scientifique ; Duyckaerts, C., Editeur scientifique ; Yves Christen, Editeur scientifique Editeur : Berlin : Springer Année de publication : 1997 Collection : Research and perspectives in Alzheimer's disease, ISSN 0945-6066 Importance : xiii, 193 p. Présentation : ill. (some col.) Format : 24 cm ISBN/ISSN/EAN : 978-3-540-62205-5 Langues : Anglais Catégories : Maladies:Etude des maladies:Maladie d'Alzheimer
Neurosciences - Santé mentale:CerveauMots-clés : "Maladie_Alzheimer--Congrès" "Physiopathologie--Congrès" "Troubles_de_la_mémoire--Congrès" Résumé : .
The fundamental relationship between the neuropathological lesions of Alzheimer's disease and the problem of what underlies the clinical syndrome has remained unsolved since the beginning of the century. In the last decade, these questions have been revisited through systematic studies of individuals with various degrees of dementia using newer immunohistochemical techniques and quantitative approaches to neuropathological study. It is now possible to have a uniform picture of Alzheimer's disease dementia as resulting from collapse of specific neural systems, as pathological changes selectively and specifically involve structures related to memory and higher cognitive functions.This book contains the proceedings of a meeting organized by the Fondation IPSEN which brought together researchers in neuropathology, molecular biology, genetics, neuropsychology, brain imagery and clinical neurology.Permalink : http://www.2em.org/pmb/opac_css/index.php?lvl=notice_display&id=1839 Connections, cognition and Alzheimer's disease [texte imprimé] / Hyman, B. T., Editeur scientifique ; Duyckaerts, C., Editeur scientifique ; Yves Christen, Editeur scientifique . - Berlin : Springer, 1997 . - xiii, 193 p. : ill. (some col.) ; 24 cm. - (Research and perspectives in Alzheimer's disease, ISSN 0945-6066) .
ISBN : 978-3-540-62205-5
Langues : Anglais
Catégories : Maladies:Etude des maladies:Maladie d'Alzheimer
Neurosciences - Santé mentale:CerveauMots-clés : "Maladie_Alzheimer--Congrès" "Physiopathologie--Congrès" "Troubles_de_la_mémoire--Congrès" Résumé : .
The fundamental relationship between the neuropathological lesions of Alzheimer's disease and the problem of what underlies the clinical syndrome has remained unsolved since the beginning of the century. In the last decade, these questions have been revisited through systematic studies of individuals with various degrees of dementia using newer immunohistochemical techniques and quantitative approaches to neuropathological study. It is now possible to have a uniform picture of Alzheimer's disease dementia as resulting from collapse of specific neural systems, as pathological changes selectively and specifically involve structures related to memory and higher cognitive functions.This book contains the proceedings of a meeting organized by the Fondation IPSEN which brought together researchers in neuropathology, molecular biology, genetics, neuropsychology, brain imagery and clinical neurology.Permalink : http://www.2em.org/pmb/opac_css/index.php?lvl=notice_display&id=1839 Exemplaires
Code-barres Cote Support Disponibilité 11525 08CHR Ouvrage Disponible Genotype - proteotype - phenotype relationships in neurodegenerative diseases / Yves Christen
Titre : Genotype - proteotype - phenotype relationships in neurodegenerative diseases Type de document : texte imprimé Auteurs : Yves Christen, Editeur scientifique ; Jeffrey L. Cummings, Editeur scientifique ; John Hardy, Editeur scientifique ; Michel Poncet, Editeur scientifique Editeur : Berlin : Springer Année de publication : 2005 Collection : Research and perspectives in Alzheimer's disease, ISSN 0945-6066 Importance : XIII-166 p. Présentation : ill. Format : 24 cm ISBN/ISSN/EAN : 978-3-540-24835-4 Langues : Anglais Catégories : Maladies:Etude des maladies:Maladie d'Alzheimer
Maladies:Génétique et ses applications:Génome
Neurosciences - Santé mentale:CerveauMots-clés : "Système_nerveux--Dégénérescence--Aspect_moléculaire" "Maladies_neurodégénératives--congrès" "Génotype--Congrès" "Phénotype--Congrès" "Système_nerveux--Dégénérescence--Congrès" Résumé : .
Protein misfolding and other abnormalities of protein metabolism are increasingly recognized as central mechanisms in the pathophysiology of neurodegenerative disorders. Amyloid beta protein disturbances in Alzheimer's disease, tau and ubiquitin protein abnormalities in frontotemporal dementias, proteasome and alphasynuclein disorders in Parkison's disease and dementia with Lewy bodies comprise central elements in these common neurodegenerative diseases. Improved understanding of role of protein dysmetabolism in neurodegeneration promises to improve diagnoses, facilitate the development of biological markers relevant to disease pathophysiology, and provide tractable therapeutic targets. This Fondation IPSEN conference summary provides an update on the latest advances of the role of protein misfolding in the pathophysiology of neurodegeberative diseases.Note de contenu : Bibliogr. à la fin des chapitres. Index Permalink : http://www.2em.org/pmb/opac_css/index.php?lvl=notice_display&id=2917 Genotype - proteotype - phenotype relationships in neurodegenerative diseases [texte imprimé] / Yves Christen, Editeur scientifique ; Jeffrey L. Cummings, Editeur scientifique ; John Hardy, Editeur scientifique ; Michel Poncet, Editeur scientifique . - Berlin : Springer, 2005 . - XIII-166 p. : ill. ; 24 cm. - (Research and perspectives in Alzheimer's disease, ISSN 0945-6066) .
ISBN : 978-3-540-24835-4
Langues : Anglais
Catégories : Maladies:Etude des maladies:Maladie d'Alzheimer
Maladies:Génétique et ses applications:Génome
Neurosciences - Santé mentale:CerveauMots-clés : "Système_nerveux--Dégénérescence--Aspect_moléculaire" "Maladies_neurodégénératives--congrès" "Génotype--Congrès" "Phénotype--Congrès" "Système_nerveux--Dégénérescence--Congrès" Résumé : .
Protein misfolding and other abnormalities of protein metabolism are increasingly recognized as central mechanisms in the pathophysiology of neurodegenerative disorders. Amyloid beta protein disturbances in Alzheimer's disease, tau and ubiquitin protein abnormalities in frontotemporal dementias, proteasome and alphasynuclein disorders in Parkison's disease and dementia with Lewy bodies comprise central elements in these common neurodegenerative diseases. Improved understanding of role of protein dysmetabolism in neurodegeneration promises to improve diagnoses, facilitate the development of biological markers relevant to disease pathophysiology, and provide tractable therapeutic targets. This Fondation IPSEN conference summary provides an update on the latest advances of the role of protein misfolding in the pathophysiology of neurodegeberative diseases.Note de contenu : Bibliogr. à la fin des chapitres. Index Permalink : http://www.2em.org/pmb/opac_css/index.php?lvl=notice_display&id=2917 Exemplaires
Code-barres Cote Support Disponibilité 11523 08CHR Ouvrage Disponible Intracellular traffic and neurodegenerative disorders / Yves Christen
Titre : Intracellular traffic and neurodegenerative disorders Type de document : texte imprimé Auteurs : Yves Christen, Editeur scientifique ; William C. Mobley, Editeur scientifique ; Peter H. St. George-Hyslop, Editeur scientifique ; Colloque Médecine et recherche (2008; Paris), Auteur Editeur : Berlin : Springer Année de publication : cop. 2009 Collection : Research and perspectives in Alzheimer's disease, ISSN 0945-6066 Importance : XIV-183 p. Présentation : ill. Format : 23 cm. ISBN/ISSN/EAN : 978-3-540-87940-4 Langues : Anglais Catégories : Maladies:Etude des maladies:Maladie d'Alzheimer
Neurosciences - Santé mentale:CerveauMots-clés : "Système_nerveux--Dégénérescence--Congrès" "Transduction_du_signal_cellulaire--Congrès" "Protéines--Transport_physiologique--Congrès" "Maladies_neurodégénératives" "Transduction_du_signal" "Transport_de_protéines" "Nervous_system--Degeneration--Pathophysiology" "Proteins--Physiological_transport" "Cellular_signal_transduction" Résumé : .
This book explores the role of sub-cellular trafficking in the pathogenesis, treatment and prevention of neurodegenerative diseases. Recent findings point to faulty trafficking as contributing to the dysfunction and degeneration of neurons and neural circuits. Increasingly, research is targeting the mechanisms responsible and means to address them therapeutically. This book investigates the ways in which sub-cellular trafficking pathways play a role both in the pathological accumulation of these misfolded proteins and in attempts to clear them. Because subcellular protein trafficking has an important role in the biology of neuronal function and survival, this also addresses how trophic factors maintain cell: cell interactions and how the underlying mechanisms may be compromised in neurodegenerative diseases. Examples where the use of such trophic factors may provide a way to modify neurodegenerative diseases are investigated.Permalink : http://www.2em.org/pmb/opac_css/index.php?lvl=notice_display&id=6013 Intracellular traffic and neurodegenerative disorders [texte imprimé] / Yves Christen, Editeur scientifique ; William C. Mobley, Editeur scientifique ; Peter H. St. George-Hyslop, Editeur scientifique ; Colloque Médecine et recherche (2008; Paris), Auteur . - Berlin : Springer, cop. 2009 . - XIV-183 p. : ill. ; 23 cm.. - (Research and perspectives in Alzheimer's disease, ISSN 0945-6066) .
ISBN : 978-3-540-87940-4
Langues : Anglais
Catégories : Maladies:Etude des maladies:Maladie d'Alzheimer
Neurosciences - Santé mentale:CerveauMots-clés : "Système_nerveux--Dégénérescence--Congrès" "Transduction_du_signal_cellulaire--Congrès" "Protéines--Transport_physiologique--Congrès" "Maladies_neurodégénératives" "Transduction_du_signal" "Transport_de_protéines" "Nervous_system--Degeneration--Pathophysiology" "Proteins--Physiological_transport" "Cellular_signal_transduction" Résumé : .
This book explores the role of sub-cellular trafficking in the pathogenesis, treatment and prevention of neurodegenerative diseases. Recent findings point to faulty trafficking as contributing to the dysfunction and degeneration of neurons and neural circuits. Increasingly, research is targeting the mechanisms responsible and means to address them therapeutically. This book investigates the ways in which sub-cellular trafficking pathways play a role both in the pathological accumulation of these misfolded proteins and in attempts to clear them. Because subcellular protein trafficking has an important role in the biology of neuronal function and survival, this also addresses how trophic factors maintain cell: cell interactions and how the underlying mechanisms may be compromised in neurodegenerative diseases. Examples where the use of such trophic factors may provide a way to modify neurodegenerative diseases are investigated.Permalink : http://www.2em.org/pmb/opac_css/index.php?lvl=notice_display&id=6013 Exemplaires
Code-barres Cote Support Disponibilité 11529 08CHR Ouvrage Disponible Presenilins and Alzheimer's disease / Yves Christen ; Younkin, S. G. ; Tanzi, Rudolph E.
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