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Macro roles for microRNAs in the life and death of neurons / Yves Christen
Titre : Macro roles for microRNAs in the life and death of neurons Type de document : texte imprimé Auteurs : Yves Christen, Editeur scientifique ; Bart de Strooper, Editeur scientifique ; Colloque Médecine et recherche (2009; Paris) Editeur : Berlin : Springer Année de publication : 2010 Collection : Research and perspectives in neurosciences, ISSN 0945-6082 Importance : xii-121 p. Présentation : ill. Format : 24 cm ISBN/ISSN/EAN : 978-3-642-04297-3 Note générale : Contributions to the Colloque Médecine et Recherche organized by the Fondation Ipsen, Paris, on April 20, 2009 Langues : Anglais Catégories : Maladies:Génétique et ses applications:Maladies génétiques
Maladies:Génétique et ses applications:Thérapie génique
Neurosciences - Santé mentale:CerveauMots-clés : "MicroARN--génétique" "Thérapie_génique" "Maladies_neurodégénératives--génétique" "Transmission_synaptique--génétique" "MicroRNAs--genetics--Congresses" "Gene_Therapy--Congresses" "Neurodegenerative_Diseases--genetics--Congresses" "Synaptic_Transmission--genetics--Congresses" "Small_interfering_RNA" "Molecular_neurobiology" "Genetic_regulation" "Neural_transmission--Disorders--Genetic_aspects" "Neural_transmission--Disorders--Gene_therapy" Résumé : .
The discovery of microRNAs has revealed an unexpected and spectacular additional level of fine tuning of the genome and how genes are used again and again in different combinations to generate the complexity that underlies for instance the brain. Since the initial studies performed in C.elegans, we have gone a far way to begin to understand how microRNA pathways can have an impact on health and disease in human. Although microRNAs are abundantly expressed in the brain, relatively little is known about the multiple functions of these RNA molecules in the nervous system. Nevertheless, we know already that microRNA pathways play major roles in the proliferation, differentiation, function and maintenance of neuronal cells. Several intriguing studies have linked microRNAs as major regulators of the neuronal phenotype, and have implicated specific microRNAs in the regulation of synapse formation and plasticity. Dysfunction of microRNA pathways is also slowly emerging as a potential important contributor to the pathogenesis of major neurodegenerative disorders such as Alzheimer’s disease and Parkinson’s disease. These novel insights appear to be particular promising for the understanding of the very frequent and badly understood sporadic forms of these diseases as compared to the genetic forms. Thus, the better understanding of the implications of this novel field of molecular biology is crucial for the broad area of neurosciences, from the fundamental aspects to the clinic, and from novel diagnostic to potentially therapeutic applications for severe neurological and possibly also psychiatric diseases.Permalink : http://www.2em.org/pmb/opac_css/index.php?lvl=notice_display&id=6105 Macro roles for microRNAs in the life and death of neurons [texte imprimé] / Yves Christen, Editeur scientifique ; Bart de Strooper, Editeur scientifique ; Colloque Médecine et recherche (2009; Paris) . - Berlin : Springer, 2010 . - xii-121 p. : ill. ; 24 cm. - (Research and perspectives in neurosciences, ISSN 0945-6082) .
ISBN : 978-3-642-04297-3
Contributions to the Colloque Médecine et Recherche organized by the Fondation Ipsen, Paris, on April 20, 2009
Langues : Anglais
Catégories : Maladies:Génétique et ses applications:Maladies génétiques
Maladies:Génétique et ses applications:Thérapie génique
Neurosciences - Santé mentale:CerveauMots-clés : "MicroARN--génétique" "Thérapie_génique" "Maladies_neurodégénératives--génétique" "Transmission_synaptique--génétique" "MicroRNAs--genetics--Congresses" "Gene_Therapy--Congresses" "Neurodegenerative_Diseases--genetics--Congresses" "Synaptic_Transmission--genetics--Congresses" "Small_interfering_RNA" "Molecular_neurobiology" "Genetic_regulation" "Neural_transmission--Disorders--Genetic_aspects" "Neural_transmission--Disorders--Gene_therapy" Résumé : .
The discovery of microRNAs has revealed an unexpected and spectacular additional level of fine tuning of the genome and how genes are used again and again in different combinations to generate the complexity that underlies for instance the brain. Since the initial studies performed in C.elegans, we have gone a far way to begin to understand how microRNA pathways can have an impact on health and disease in human. Although microRNAs are abundantly expressed in the brain, relatively little is known about the multiple functions of these RNA molecules in the nervous system. Nevertheless, we know already that microRNA pathways play major roles in the proliferation, differentiation, function and maintenance of neuronal cells. Several intriguing studies have linked microRNAs as major regulators of the neuronal phenotype, and have implicated specific microRNAs in the regulation of synapse formation and plasticity. Dysfunction of microRNA pathways is also slowly emerging as a potential important contributor to the pathogenesis of major neurodegenerative disorders such as Alzheimer’s disease and Parkinson’s disease. These novel insights appear to be particular promising for the understanding of the very frequent and badly understood sporadic forms of these diseases as compared to the genetic forms. Thus, the better understanding of the implications of this novel field of molecular biology is crucial for the broad area of neurosciences, from the fundamental aspects to the clinic, and from novel diagnostic to potentially therapeutic applications for severe neurological and possibly also psychiatric diseases.Permalink : http://www.2em.org/pmb/opac_css/index.php?lvl=notice_display&id=6105 Exemplaires
Code-barres Cote Support Disponibilité 11608 09CHR Ouvrage Disponible Memories: molecules and circuits / Yves Christen
Titre : Memories: molecules and circuits Type de document : texte imprimé Auteurs : Yves Christen, Editeur scientifique ; Bruno Bontempi, Editeur scientifique ; Alcino J. Silva, Editeur scientifique ; Fondation IPSEN pour la recherche thérapeutique. Editeur : Berlin : Springer Année de publication : 2007 Collection : Research and perspectives in neurosciences, ISSN 0945-6082 Importance : XIII-182 p. Présentation : ill. Format : 24 cm ISBN/ISSN/EAN : 978-3-540-45698-8 Note générale : D'après les actes du symposium organisé par la Fondation Ipsen le 24 avril 2006
Notes bibliogr. en fin de chap. IndexLangues : Anglais Catégories : Neurosciences - Santé mentale:Cerveau Mots-clés : "Souvenir--Aspect_physiologique" "Mémoire--Aspect_physiologique" "Mémoire_à_long_terme--Aspect_physiologique" Mémoire "Cerveau--Psychophysiologie--Congrès" "Mémoire--Aspect_physiologique--Congrès" "Apprentissage--Aspect_physiologique--Congrès" Résumé : .
The questions of how, where and when memory traces are formed in the brain remain central issues in Cognitive Neuroscience. How do neuronal systems encode, consolidate and retrieve memory? How are memories embedded into complex neuronal networks? How do molecular mechanisms modulate the neuronal plasticity and functioning of these networks during memory processing? What are the fundamental units of computation in the brain? Thanks to the development of novel approaches, including transgenic techniques, functional brain imaging, multiple cell recording, functional genomics and proteomics, the last decade has been witness to dramatic advances in the neurobiology, neuroanatomy, neurophysiology and neuropathology of learning and memory processes.
This volume surveys the recent advances and provides an integrative view of molecular, cellular, and systems level mechanisms underlying cognitive processes in both animals and humans. Current state of the art and future avenues are discussed by distinguished scientists who provide not only an overview of the underlying neurobiology of cognitive processes from a basic science standpoint, but who also focus on clinical and therapeutic aspects surrounding impairments associated with disorders that affect cognition.Permalink : http://www.2em.org/pmb/opac_css/index.php?lvl=notice_display&id=6102 Memories: molecules and circuits [texte imprimé] / Yves Christen, Editeur scientifique ; Bruno Bontempi, Editeur scientifique ; Alcino J. Silva, Editeur scientifique ; Fondation IPSEN pour la recherche thérapeutique. . - Berlin : Springer, 2007 . - XIII-182 p. : ill. ; 24 cm. - (Research and perspectives in neurosciences, ISSN 0945-6082) .
ISBN : 978-3-540-45698-8
D'après les actes du symposium organisé par la Fondation Ipsen le 24 avril 2006
Notes bibliogr. en fin de chap. Index
Langues : Anglais
Catégories : Neurosciences - Santé mentale:Cerveau Mots-clés : "Souvenir--Aspect_physiologique" "Mémoire--Aspect_physiologique" "Mémoire_à_long_terme--Aspect_physiologique" Mémoire "Cerveau--Psychophysiologie--Congrès" "Mémoire--Aspect_physiologique--Congrès" "Apprentissage--Aspect_physiologique--Congrès" Résumé : .
The questions of how, where and when memory traces are formed in the brain remain central issues in Cognitive Neuroscience. How do neuronal systems encode, consolidate and retrieve memory? How are memories embedded into complex neuronal networks? How do molecular mechanisms modulate the neuronal plasticity and functioning of these networks during memory processing? What are the fundamental units of computation in the brain? Thanks to the development of novel approaches, including transgenic techniques, functional brain imaging, multiple cell recording, functional genomics and proteomics, the last decade has been witness to dramatic advances in the neurobiology, neuroanatomy, neurophysiology and neuropathology of learning and memory processes.
This volume surveys the recent advances and provides an integrative view of molecular, cellular, and systems level mechanisms underlying cognitive processes in both animals and humans. Current state of the art and future avenues are discussed by distinguished scientists who provide not only an overview of the underlying neurobiology of cognitive processes from a basic science standpoint, but who also focus on clinical and therapeutic aspects surrounding impairments associated with disorders that affect cognition.Permalink : http://www.2em.org/pmb/opac_css/index.php?lvl=notice_display&id=6102 Exemplaires
Code-barres Cote Support Disponibilité 11605 09CHR Ouvrage Disponible Neurobiology of Human Values / Yves Christen
Titre : Neurobiology of Human Values Type de document : texte imprimé Auteurs : Yves Christen, Editeur scientifique ; Jean-Pierre Changeux, Editeur scientifique ; Antonio R. Damasio, Editeur scientifique ; Wolf Singer, Editeur scientifique Editeur : Berlin : Springer Année de publication : 2005 Collection : Research and perspectives in neurosciences, ISSN 0945-6082 Importance : 160 p. Format : 24 cm ISBN/ISSN/EAN : 978-3-540-26253-4 Langues : Anglais Mots-clés : Neurobiologie "Psychologie_cognitive" Neuropsychologie "Norme--morale" "Développement_moral" "Création--esthétique--Aspect_psychologique" Résumé : .
Man has been pondering for centuries over the basis of his own ethical and aesthetic values. Until recent times, such issues were primarily fed by the thinking of philosophers, moralists and theologists, or by the findings of historians or sociologists relating to universality or variations in these values within various populations. Now, thanks to new discoveries and development in neuroscience, neurology, psychology, ethology, and evolutionary studies, it becomes possible to understand the biological basis of goodness, beauty and truth. The symposium organised by the Fondation Ipsen, of which this work constitutes the proceedings, is one of the first events seeking to provide an overview of the neurobiology of human values. It leads to a better understanding of how the structure and functioning of the brain make possible ethical or aesthetic judgments and provide arguments in favour of the Darwinian assumption of a naturality of social and moral behavior.Permalink : http://www.2em.org/pmb/opac_css/index.php?lvl=notice_display&id=2918 Neurobiology of Human Values [texte imprimé] / Yves Christen, Editeur scientifique ; Jean-Pierre Changeux, Editeur scientifique ; Antonio R. Damasio, Editeur scientifique ; Wolf Singer, Editeur scientifique . - Berlin : Springer, 2005 . - 160 p. ; 24 cm. - (Research and perspectives in neurosciences, ISSN 0945-6082) .
ISBN : 978-3-540-26253-4
Langues : Anglais
Mots-clés : Neurobiologie "Psychologie_cognitive" Neuropsychologie "Norme--morale" "Développement_moral" "Création--esthétique--Aspect_psychologique" Résumé : .
Man has been pondering for centuries over the basis of his own ethical and aesthetic values. Until recent times, such issues were primarily fed by the thinking of philosophers, moralists and theologists, or by the findings of historians or sociologists relating to universality or variations in these values within various populations. Now, thanks to new discoveries and development in neuroscience, neurology, psychology, ethology, and evolutionary studies, it becomes possible to understand the biological basis of goodness, beauty and truth. The symposium organised by the Fondation Ipsen, of which this work constitutes the proceedings, is one of the first events seeking to provide an overview of the neurobiology of human values. It leads to a better understanding of how the structure and functioning of the brain make possible ethical or aesthetic judgments and provide arguments in favour of the Darwinian assumption of a naturality of social and moral behavior.Permalink : http://www.2em.org/pmb/opac_css/index.php?lvl=notice_display&id=2918 Exemplaires
Code-barres Cote Support Disponibilité 11603 09CHR Ouvrage Disponible Neurobiology of "Umwelt" / Yves Christen
Titre : Neurobiology of "Umwelt" : how living beings perceive the world Type de document : texte imprimé Auteurs : Yves Christen, Editeur scientifique ; Alain Berthoz, Editeur scientifique Editeur : Berlin : Springer Année de publication : 2009 Collection : Research and perspectives in neurosciences, ISSN 0945-6082 Importance : xii-158 p. Présentation : ill. en noir et en coul. Format : 24 cm ISBN/ISSN/EAN : 978-3-540-85896-6 Langues : Anglais Catégories : Neurosciences - Santé mentale:Neurosciences Mots-clés : Perception Neurobiologie "Perception--physiologie" Comportement "Environnement_social" "Psychologie_comparative--méthodes" Résumé : .
At the beginning of the 20th century, German biologist Jakob von Uexküll created the concept of "Umwelt" to denote the environment as experienced by a subject. This concept of environment differs from the idea of passive surroundings and is defined not just by physical surroundings, but is rather a "subjective universe", a space weighted with meaning. Based on this perspective, a living organism, no matter how basic (such as the tick studied by von Uexküll), created its own universe when it interacts with the world and as this same time the organism reshapes it.
Today, neuroscience provides a new way to look at the brain’s capability to create a representation of the world. At the same time behavioural specialists are demonstrating that animals have a richer mental universe than previously known. Philosophical reflection thus finds itself with more experimental and objective data as well. Nearly a century after the publication of von Uexküll’s founding work ( "Umwelt und Innenwelt der Tiere" was published in 1909), neurobiologists, psychologists, sociologists, anthropologists, ethologists, and philosophers revisit his mail concept at the light of modern science in this volume.Permalink : http://www.2em.org/pmb/opac_css/index.php?lvl=notice_display&id=6104 Neurobiology of "Umwelt" : how living beings perceive the world [texte imprimé] / Yves Christen, Editeur scientifique ; Alain Berthoz, Editeur scientifique . - Berlin : Springer, 2009 . - xii-158 p. : ill. en noir et en coul. ; 24 cm. - (Research and perspectives in neurosciences, ISSN 0945-6082) .
ISBN : 978-3-540-85896-6
Langues : Anglais
Catégories : Neurosciences - Santé mentale:Neurosciences Mots-clés : Perception Neurobiologie "Perception--physiologie" Comportement "Environnement_social" "Psychologie_comparative--méthodes" Résumé : .
At the beginning of the 20th century, German biologist Jakob von Uexküll created the concept of "Umwelt" to denote the environment as experienced by a subject. This concept of environment differs from the idea of passive surroundings and is defined not just by physical surroundings, but is rather a "subjective universe", a space weighted with meaning. Based on this perspective, a living organism, no matter how basic (such as the tick studied by von Uexküll), created its own universe when it interacts with the world and as this same time the organism reshapes it.
Today, neuroscience provides a new way to look at the brain’s capability to create a representation of the world. At the same time behavioural specialists are demonstrating that animals have a richer mental universe than previously known. Philosophical reflection thus finds itself with more experimental and objective data as well. Nearly a century after the publication of von Uexküll’s founding work ( "Umwelt und Innenwelt der Tiere" was published in 1909), neurobiologists, psychologists, sociologists, anthropologists, ethologists, and philosophers revisit his mail concept at the light of modern science in this volume.Permalink : http://www.2em.org/pmb/opac_css/index.php?lvl=notice_display&id=6104 Exemplaires
Code-barres Cote Support Disponibilité 11607 09CHR Ouvrage Disponible New frontiers in social neuroscience / Fondation IPSEN pour la recherche thérapeutique.
Titre : New frontiers in social neuroscience Type de document : texte imprimé Auteurs : Fondation IPSEN pour la recherche thérapeutique., Auteur ; Jean Decety, Editeur scientifique ; Yves Christen, Editeur scientifique Editeur : Berlin : Springer Année de publication : cop. 2014 Collection : Research and perspectives in neurosciences, ISSN 0945-6082 Importance : 1 vol. (xiv, 219 p.) Présentation : ill. en coul. Format : 24 cm ISBN/ISSN/EAN : 978-3-319-02903-0 Catégories : Neurosciences - Santé mentale:Neurosciences Mots-clés : "Développement_neurologique" "Psychologie_sociale" Neurosciences "Developmental_neurobiology" "Social_psychology" Résumé : .
Traditionally, neuroscience has considered the nervous system as an isolated entity and largely ignored influences of the social environments in which humans and many animal species live. However, there is mounting evidence that the social environment affects behavior across species, from microbes to humans.
This volume brings together scholars who work with animal and human models of social behavior to discuss the challenges and opportunities in this interdisciplinary academic fieldPermalink : http://www.2em.org/pmb/opac_css/index.php?lvl=notice_display&id=6802 New frontiers in social neuroscience [texte imprimé] / Fondation IPSEN pour la recherche thérapeutique., Auteur ; Jean Decety, Editeur scientifique ; Yves Christen, Editeur scientifique . - Berlin : Springer, cop. 2014 . - 1 vol. (xiv, 219 p.) : ill. en coul. ; 24 cm. - (Research and perspectives in neurosciences, ISSN 0945-6082) .
ISBN : 978-3-319-02903-0
Catégories : Neurosciences - Santé mentale:Neurosciences Mots-clés : "Développement_neurologique" "Psychologie_sociale" Neurosciences "Developmental_neurobiology" "Social_psychology" Résumé : .
Traditionally, neuroscience has considered the nervous system as an isolated entity and largely ignored influences of the social environments in which humans and many animal species live. However, there is mounting evidence that the social environment affects behavior across species, from microbes to humans.
This volume brings together scholars who work with animal and human models of social behavior to discuss the challenges and opportunities in this interdisciplinary academic fieldPermalink : http://www.2em.org/pmb/opac_css/index.php?lvl=notice_display&id=6802 Exemplaires
Code-barres Cote Support Disponibilité 11609 09CHR Ouvrage Disponible Retrotransposition, diversity, and the brain / Yves Christen
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